Overview
| 别名 | Kininogen-1; Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK; Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin; Ile-Ser-Bradykinin); Bradykinin; Kallidin I); Lysyl-bradykinin; Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] |
| 基因名 | Kininogen-1 |
| UniProt ID | P01042 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 5K5-T7-O7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 71 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor or Williams-Fitzgerald-Flaujeac factor, is a multifunctional protein that plays crucial roles in blood coagulation, inflammation, and pain perception. It is encoded by the KNG1 gene and exists in two isoforms: high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK). HMWK is essential for blood clotting and is cleaved by kallikrein to release bradykinin, a potent vasodilator and pain mediator. KNG1 is also a constituent of the kallikrein-kinin system, which regulates blood pressure and inflammation. Mutations or deficiencies in KNG1 are associated with various disorders, including Fletcher factor deficiency, a rare bleeding disorder, and hereditary angioedema, characterized by recurrent episodes of severe swelling. Additionally, altered KNG1 levels have been linked to inflammatory conditions like rheumatoid arthritis and sepsis. |
检测原理