Overview
| 别名 | Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha; TGF-alpha; EGF-like TGF; ETGF; TGF type 1] |
| 基因名 | TGFA |
| UniProt ID | P01135 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 5Y6-S1-P7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 17 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Transforming growth factor-alpha (TGFA) is a potent growth factor that plays a significant role in cell proliferation, differentiation, and tissue repair. It is synthesized as a precursor protein and is involved in various physiological processes, including wound healing and tissue regeneration. TGFA functions by activating the epidermal growth factor receptor (EGFR), leading to downstream signaling that promotes cellular growth and survival. Dysregulation of TGFA has been implicated in several diseases, particularly in cancer, where its overexpression can contribute to tumor growth and metastasis. Elevated levels of TGFA have been observed in various malignancies, including breast and lung cancers, where it may facilitate angiogenesis and immune evasion. Additionally, TGFA has been associated with inflammatory conditions such as chronic obstructive pulmonary disease (COPD) and liver fibrosis. |
检测原理