Overview
| 别名 | Lutropin subunit beta; Lutropin beta chain; Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-beta |
| 基因名 | LHB |
| UniProt ID | P01229 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2W8-U2-I4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 15 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Luteinizing hormone subunit beta (LHB) is the hormone-specific beta chain of luteinizing hormone (LH), a pituitary glycoprotein essential for reproductive function. It heterodimerizes with a common alpha-subunit to form bioactive LH, which signals through the LH receptor (LHCGR) to regulate gonadal steroidogenesis, ovulation in females, and testosterone production by Leydig cells in males. The LHB subunit features a stable cystine-knot fold and a characteristic seatbelt region that secures the heterodimeric complex. Clinically, pathogenic variants in the LHB gene lead to isolated LH deficiency, a condition characterized by hypogonadotropic hypogonadism. Affected individuals typically present with delayed or absent puberty, infertility, and low sex steroid levels, resulting in anovulation in females and impaired spermatogenesis in males. Disruption of the LH signaling axis is also a recognized cause of Leydig cell hypoplasia and various forms of male pseudohermaphroditism. |
检测原理