Overview
| 别名 | Immunoglobulin heavy constant gamma 1; Ig gamma-1 chain C region; Ig gamma-1 chain C region EU; Ig gamma-1 chain C region KOL; Ig gamma-1 chain C region NIE |
| 基因名 | Human IgG1 |
| UniProt ID | P01857 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9Z8-Y5-S9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 43 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Human IgG1 is the most abundant subclass of IgG antibodies, representing 60-70% of total IgG in human serum. IgG1 has a flexible structure with a longer hinge region compared to other IgG subclasses, allowing for greater mobility of the Fab fragments relative to the Fc region. This flexibility affects IgG1's ability to bind and activate the classical complement pathway through C1q, as well as its binding to Fc receptors (FcγR) on phagocytic cells to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis. Deficiencies or abnormalities in IgG1 levels or function have been associated with various disease states. IgG1 deficiency is often linked to hypogammaglobulinemia, as IgG1 makes up the majority of total IgG, and low IgG1 levels can lead to increased susceptibility to viral infections. Conversely, excessive or dysregulated IgG1 responses have been implicated in autoimmune diseases and allergic disorders. |
检测原理