Overview
| 别名 | Alpha-crystallin A chain; Heat shock protein beta-4; HspB4; Heat shock protein family B member 4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162] |
| 基因名 | alpha A Crystallin |
| UniProt ID | P02489 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9E7-X9-H5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 19 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Crystallin alpha A (CRYAA) is a protein encoded by the CRYAA gene in humans, primarily found in the vertebrate eye lens. It belongs to the small heat-shock protein family and plays a crucial role in maintaining the transparency and refractive index of the lens. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, with alpha-A being preferentially restricted to the lens and alpha-B expressed widely in many tissues and organs. The protein acts as a molecular chaperone, holding proteins in large soluble aggregates rather than renaturing them, and its post-translational modifications can decrease its chaperone activity. The alpha-A and alpha-B subunits form heterogeneous aggregates with a 3:1 ratio, respectively, and are involved in the intracellular architecture and autokinase activity. Defects in the CRYAA gene can cause autosomal dominant congenital cataract (ADCC), a condition characterized by lens opacity at birth. |
检测原理