Overview
| 别名 | Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase] |
| 基因名 | MMP1 |
| UniProt ID | P03956 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2D3-K5-W6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 54 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Matrix Metalloproteinase 1 (MMP1), also known as interstitial collagenase, is an enzyme that plays a vital role in the degradation of extracellular matrix components, particularly collagen. This protein is crucial for normal physiological processes such as tissue remodeling, wound healing, and embryogenesis. MMP1 is expressed in various tissues, including the skin, lung, and synovium, and its activity is tightly regulated by tissue inhibitors of metalloproteinases (TIMPs). Dysregulation of MMP1 has been implicated in several diseases, particularly in inflammatory conditions and cancer. Elevated levels of MMP1 are associated with rheumatoid arthritis, where it contributes to joint destruction, and with various cancers, including breast and prostate cancer, where it enhances tumor invasion and metastasis. The dual role of MMP1 in both normal tissue homeostasis and disease progression highlights its potential as a therapeutic target. |
检测原理