Overview
| 别名 | Insulin-like growth factor 1; Insulin-like growth factor I; IGF-I; Mechano growth factor; MGF; Somatomedin-C |
| 基因名 | IGF1 |
| UniProt ID | P05019 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1A3-Z2-J4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 21 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Insulin-like growth factor I (IGF-1), also known as somatomedin C, is a peptide hormone that plays a crucial role in growth and development. It is primarily synthesized in the liver in response to growth hormone (GH) stimulation and consists of 70 amino acids, featuring three intramolecular disulfide bridges that contribute to its stability. IGF-1 mediates various anabolic processes, promoting cell proliferation, differentiation, and survival across multiple tissues, including muscle, cartilage, and bone. Dysregulation of IGF-1 signaling has been implicated in several diseases, elevated levels are associated with cancer progression, particularly in breast and prostate cancers, where it can enhance tumor cell proliferation and survival. Additionally, low IGF-1 levels have been linked to growth disorders and age-related conditions. |
检测原理