Overview
| 别名 | Arginase-1; Liver-type arginase; Type I arginase |
| 基因名 | Liver Arginase |
| UniProt ID | P05089 |
| 反应种属 | Human,Rat |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4Y3-T6-U2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 34 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Arginase-1 (ARG1) is a crucial enzyme in the urea cycle, primarily responsible for converting L-arginine into L-ornithine and urea, thus facilitating the detoxification of ammonia in mammals. This enzyme is a member of the ureohydrolase family and operates as a trimer, requiring manganese ions for its catalytic activity. It plays a significant role in nitrogen metabolism by removing excess nitrogen from the body, which is particularly important in liver cells where it is predominantly expressed. The enzyme's activity is tightly regulated, as alterations can impact various physiological processes, including immune responses and cellular signaling pathways. Mutations or deficiencies in ARG1 can lead to arginase deficiency, a rare metabolic disorder characterized by hyperargininemia, which results in elevated levels of arginine and ammonia in the blood. This condition can cause severe neurological symptoms, including developmental delays and spasticity due to ammonia's neurotoxic effects. |
检测原理