Overview
| 别名 | Integrin beta-1; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD antigen CD29 |
| 基因名 | ITGB1 |
| UniProt ID | P05556 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4Z7-Z5-R9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 88 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Integrin subunit beta 1 (ITGB1) is a vital component of the integrin family, functioning as a transmembrane glycoprotein that forms heterodimers with various alpha subunits, facilitating crucial cellular processes such as adhesion, migration, and signaling. ITGB1 plays a significant role in numerous physiological functions, including embryogenesis and tissue repair, and is implicated in the pathogenesis of several diseases, notably cancers like gallbladder and breast cancer. Dysregulation of ITGB1 has been linked to tumor progression and metastasis, making it a potential prognostic biomarker and therapeutic target. The gene encoding ITGB1 is located on chromosome 10p11.22 and produces multiple isoforms, with the β1-A isoform being the most extensively studied. |
检测原理