Overview
| 别名 | Insulin receptor; IR; CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] |
| 基因名 | Insulin Receptor |
| UniProt ID | P06213 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 7D4-R1-W3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 156 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Insulin receptor (INSR) is a transmembrane receptor tyrosine kinase that plays a central role in mediating the effects of insulin on glucose homeostasis and metabolism. Structurally, the mature receptor is a tetramer composed of two extracellular α-subunits, responsible for insulin binding, and two transmembrane β-subunits, which possess intrinsic tyrosine kinase activity and mediate intracellular signaling upon insulin binding. The INSR gene undergoes alternative splicing to produce two main isoforms, IR-A and IR-B, which differ in their tissue distribution and functional properties. Upon insulin binding, the receptor undergoes autophosphorylation and activates downstream signaling pathways that regulate glucose uptake, lipid metabolism, cell growth, and survival. Dysfunction or mutations in INSR can impair insulin signaling, leading to insulin resistance and contributing to metabolic disorders such as type 2 diabetes and, less commonly, rare syndromes of severe insulin resistance; aberrant signaling is also implicated in certain cancers due to its role in cell proliferation and apoptosis. |
检测原理