Overview
| 别名 | Tyrosine-protein kinase Fes/Fps; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes |
| 基因名 | FES |
| UniProt ID | P07332 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7E6-A2-S7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 93 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Tyrosine-protein kinase Fes/Fps (FES) is a non-receptor tyrosine kinase that plays a significant role in various cellular processes, including cell proliferation, differentiation, and survival. FES is primarily expressed in hematopoietic cells and is involved in signaling pathways that regulate immune responses and inflammation. Its activation is associated with the regulation of cytoskeletal dynamics and cellular adhesion, which are crucial for normal immune function. Dysregulation of FES has been implicated in several diseases, such as leukemia and lymphoma. Elevated FES expression has been observed in acute myeloid leukemia (AML), where it may contribute to oncogenic signaling and promote tumor cell survival. Additionally, FES has been linked to autoimmune diseases, including rheumatoid arthritis, where its activity can exacerbate inflammation and joint damage. |
检测原理