Overview
| 别名 | Procathepsin L; Cathepsin L1; Major excreted protein; MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] |
| 基因名 | CTSL |
| UniProt ID | P07711 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8H1-H2-Q5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 37 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cathepsin L (CTSL) is a lysosomal cysteine protease belonging to the papain-like family, widely expressed in eukaryotic cells and primarily involved in intracellular protein catabolism, including the degradation of collagen, elastin, and other proteins essential for cellular turnover and growth regulation. It plays a critical role in processes such as antigen processing, cell cycle progression, apoptosis, and the turnover of both intracellular and secreted proteins. Cathepsin L is also secreted in its pro-form and is a major excreted protein in certain malignantly transformed cells, contributing to tumor invasion, metastasis, and bone resorption. Beyond its physiological functions, CTSL is implicated in pathological conditions, including facilitating viral entry (notably SARS-CoV-2), promoting tissue inflammation when secreted by immune cells, and contributing to diseases such as myopathies, myocardial ischemia, and cancer progression. |
检测原理