Overview
| 别名 | Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] |
| 基因名 | IGF1R |
| UniProt ID | P08069 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 3N4-W4-E4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 154 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Insulin-like growth factor 1 receptor (IGF1R) is a transmembrane receptor that plays a critical role in cellular growth, development, and metabolism by mediating the effects of insulin-like growth factor 1 (IGF-1). It is composed of two alpha and two beta subunits, forming a tyrosine kinase receptor that activates various signaling pathways, including the PI3K/Akt and MAPK pathways, which are essential for cell proliferation and survival. Dysregulation of IGF1R has been implicated in several diseases, particularly cancer. Elevated IGF1R levels have been observed in various malignancies, including breast, prostate, and colorectal cancers, contributing to aggressive tumor behavior. Moreover, IGF1R is involved in metabolic disorders such as obesity and type 2 diabetes, where it affects insulin signaling and glucose homeostasis. |
检测原理