Overview
| 别名 | Beta-glucuronidase; Beta-G1 |
| 基因名 | beta Glucuronidase |
| UniProt ID | P08236 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9W9-Y9-G7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 74 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Glucuronidase beta (beta Glucuronidase) is a lysosomal glycosidase enzyme essential for the degradation of glycosaminoglycans. It catalyzes the hydrolysis of beta-D-glucuronic acid residues from the non-reducing termini of various glucuronide conjugates. This enzymatic process is a critical step in the phase II detoxification pathway, facilitating the elimination of drugs, hormones, and environmental toxins by releasing their aglycone forms. The enzyme functions as a homotetramer and operates optimally at an acidic pH within the lysosome. Mutations in the GUSB gene lead to Sly syndrome, also known as mucopolysaccharidosis type VII, a rare lysosomal storage disorder characterized by the accumulation of undegraded glycosaminoglycans in various tissues. Additionally, elevated extracellular beta-glucuronidase activity has been associated with the reactivation of toxic compounds in certain cancers. |
检测原理