Overview
| 别名 | Interleukin-3; IL-3; Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor |
| 基因名 | IL3 |
| UniProt ID | P08700 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6Q1-B7-N5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 17 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Interleukin-3 (IL-3) is a cytokine primarily produced by activated T cells, playing a pivotal role in the immune system by regulating the proliferation and differentiation of various blood cell types. It acts as a multi-lineage growth factor, stimulating hematopoietic stem cells to differentiate into myeloid progenitor cells and promoting the survival of monocyte/macrophage progenitors, which are crucial for immune responses against pathogens. IL-3 also influences the inflammatory response, and its dysregulation has been implicated in various diseases, including hematological malignancies and autoimmune disorders. The signaling pathways activated by IL-3, particularly through its receptor, involve the JAK2/STAT5 pathway, which is essential for gene expression regulation and cell survival. Understanding IL-3's functions and its relationship with disease can provide insights into potential therapeutic targets for immune-related conditions and cancers. |
检测原理