Overview
| 别名 | Coagulation factor VII; Proconvertin; Serum prothrombin conversion accelerator; SPCA; Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain] |
| 基因名 | F7 |
| UniProt ID | P08709 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9D5-J5-P8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 51 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Coagulation factor VII (F7) is a vitamin K-dependent serine protease that initiates the extrinsic coagulation pathway. Produced in the liver, it circulates as a zymogen and contains a Gla-rich domain for membrane binding and EGF-like domains for protein interactions. Upon vascular injury, F7 binds to exposed tissue factor (TF) to form the FVIIa-TF complex, which allosterically activates the proteolysis of factors IX and X, leading to thrombin generation and fibrin clot formation. Clinically, mutations in the F7 gene cause factor VII deficiency, a rare autosomal recessive bleeding disorder. Symptoms range from mild bruising to life-threatening hemorrhages, and the severity of the condition is often exacerbated by vitamin K deficiency or impaired protein activation. |
检测原理