Overview
| 别名 | Stromelysin-2; SL-2; Matrix metalloproteinase-10; MMP-10; Transin-2 |
| 基因名 | MMP10 |
| UniProt ID | P09238 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7L9-Y8-T7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 54 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Stromelysin-2, also known as Matrix Metalloproteinase-10 (MMP-10), is a secreted enzyme that belongs to the matrix metalloproteinase family, which is involved in the degradation of the extracellular matrix. MMP-10 plays essential roles in various physiological processes, including tissue remodeling, wound healing, and skeletal development. It is particularly noted for its ability to degrade components such as proteoglycans and fibronectin. Dysregulation of MMP-10 has been implicated in several pathological conditions, including cancer, where its overexpression is associated with tumor progression and metastasis. For example, elevated levels of MMP-10 have been linked to increased cancer stem cell vitality and poor prognosis in oral cancer patients. Additionally, MMP-10's involvement in inflammatory processes suggests a role in diseases such as arthritis and cardiovascular disorders. |
检测原理