Overview
| 别名 | Cryptic protein; Cryptic family protein 1 |
| 基因名 | CFC1 |
| UniProt ID | P0CG37 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4I4-I7-W7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 24 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cryptic, EGF-CFC family member 1 (CFC1) is a protein encoded by the CFC1 gene located on chromosome 2 and is a member of the EGF-CFC family, which includes structurally related proteins characterized by a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. These proteins act as competence factors during early embryogenesis, playing essential roles in mesoderm and endoderm formation, anterior/posterior axis establishment, and particularly in left-right (L/R) axis patterning. CFC1 is necessary for proper signaling of the TGFβ-related gene nodal during gastrulation and L/R asymmetry development, and its expression is critical in early heart development. Mutations in CFC1 are associated with developmental defects such as autosomal visceral heterotaxy and congenital heart disease. |
检测原理