Overview
| 别名 | Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD antigen CD222 |
| 基因名 | IGF2R |
| UniProt ID | P11717 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1V4-P8-O8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 274 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Insulin-like growth factor 2 receptor (IGF2R), also known as the cation-independent mannose-6-phosphate receptor, is a large, multifunctional transmembrane protein ubiquitously expressed in human tissues. Structurally, IGF2R is composed of a 300-kDa polypeptide with a substantial extracellular region containing 15 homologous domains, a single transmembrane segment, and a short cytoplasmic tail. Its primary functions include binding and internalizing insulin-like growth factor 2 (IGF2) to regulate its signaling, as well as trafficking lysosomal enzymes by recognizing mannose-6-phosphate tags and directing these enzymes from the Golgi apparatus to lysosomes. Specific domains within the extracellular region are responsible for binding IGF2 and phosphomannosyl residues, with domain 11 being critical for IGF2 binding and domains 3, 5, and 9 for mannose-6-phosphate recognition. Beyond its physiological roles, IGF2R is implicated in disease, serving as a prognostic marker in several cancers, such as cervical, kidney, and liver carcinomas, and its dysfunction can disrupt growth factor regulation and lysosomal enzyme trafficking. |
检测原理