Overview
| 别名 | Fibroblast growth factor 5; FGF-5; Heparin-binding growth factor 5; HBGF-5; Smag-82 |
| 基因名 | FGF5 |
| UniProt ID | P12034 |
| 反应种属 | Human |
| 应用 | WB,IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9P6-Q4-X5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 29 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:500; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Fibroblast Growth Factor 5 (FGF5) is a protein encoded by the FGF5 gene in humans, consisting of 268 amino acids and weighing approximately 29.1 kDa. It plays a crucial role in various biological processes, particularly in regulating the hair growth cycle by signaling the transition from the anagen (growth) phase to the catagen (regression) phase. The protein interacts with specific tyrosine kinase receptors (FGFR1), and its expression is notably high during the late anagen phase of hair follicles. Mutations in FGF5 have been linked to conditions such as familial trichomegaly, characterized by excessively long eyelashes and hair, and androgenetic alopecia, where polymorphisms in FGF5 are associated with male pattern baldness. Additionally, FGF5 has been implicated in other diseases; for example, it has protective roles against sepsis-induced cardiac injury by modulating cellular pathways. |
检测原理