Overview
| 别名 | Myosin light chain 4; Myosin light chain 1; embryonic muscle/atrial isoform; Myosin light chain alkali GT-1 isoform |
| 基因名 | MYL4 |
| UniProt ID | P12829 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8M2-X2-S2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 21 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Myosin light chain 4 (MYL4), also known as atrial light chain-1 (ALC-1), is a regulatory light chain of the myosin II complex primarily expressed in fetal cardiac and skeletal muscle and adult atria. It features an alanine-proline-rich N-terminal extension that serves as a spacer for actin binding, thereby modulating myosin cross-bridge cycling kinetics to enhance contractile velocity and shortening rates. Its expression is tightly regulated by E-boxes and CArG box promoters. While ALC-1 typically supports atrial function, its re-expression in the ventricles is a hallmark of various cardiac pathologies. Clinically, mutations in the MYL4 gene are associated with familial atrial fibrillation, and its reactivation in adult ventricular tissue is observed in hypertrophic, dilated, and ischemic cardiomyopathies, where it correlates with altered myofilament calcium sensitivity and impaired systolic pressure. |
检测原理