Overview
| 别名 | Lysosome-associated membrane glycoprotein 2; LAMP-2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B; LGP-96; CD antigen CD107b |
| 基因名 | LAMP2 |
| UniProt ID | P13473 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6N9-T3-N8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 44 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:2000-1:3000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Lysosomal associated membrane protein 2 (LAMP2) is a heavily glycosylated integral membrane protein that maintains lysosomal integrity and facilitates various autophagic pathways. It exists as three isoforms—LAMP2A, LAMP2B, and LAMP2C—generated through alternative splicing. LAMP2A serves as the primary receptor for chaperone-mediated autophagy, facilitating the selective degradation of cytosolic proteins to regulate metabolism. LAMP2B is essential for autophagosome-lysosome fusion, particularly in cardiomyocytes, while LAMP2C mediates the degradation of nucleic acids. Beyond autophagy, LAMP2 protects the lysosomal membrane from autodigestion and aids in cell adhesion. Clinically, mutations in LAMP2 cause Danon disease, a condition characterized by severe cardiomyopathy and myopathy. Additionally, its upregulation is linked to glioblastoma progression, and its surface expression on various cancer cells is associated with increased metastatic potential. |
检测原理