Overview
| 别名 | Ribonuclease inhibitor; Placental ribonuclease inhibitor; Placental RNase inhibitor; Ribonuclease/angiogenin inhibitor 1; RAI |
| 基因名 | RNH1 |
| UniProt ID | P13489 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5U1-H6-E7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 49 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ribonuclease/angiogenin inhibitor 1 (RNH1) is a cytosolic leucine-rich repeat (LRR) protein that serves as a potent inhibitor of pancreatic-type ribonucleases, including RNase 1, 2, 4, and angiogenin. It forms a horseshoe-shaped structure that binds these enzymes with femtomolar affinity, protecting intracellular RNA from degradation and inhibiting pro-angiogenic activities. Beyond its role in RNA stability, RNH1 associates with ribosomes to regulate mRNA-specific translation, notably promoting the translation of the erythroid transcription factor GATA1 during erythropoiesis. Clinically, biallelic loss-of-function variants in RNH1 cause a severe congenital disorder characterized by neurodevelopmental delay, seizures, myopathy, and cataracts. It is also implicated in hematopoiesis, inflammatory control, and oxidative stress defense. |
检测原理