Overview
| 别名 | Endoplasmin; 94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Heat shock protein family C member 4; Tumor rejection antigen 1; gp96 homolog |
| 基因名 | GRP94 |
| UniProt ID | P14625 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1O8-Y6-Z6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 92 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Heat shock protein 90 beta family member 1 (HSP90B1), also known as endoplasmic reticulum chaperone Grp94, is a molecular chaperone that plays a crucial role in protein folding and cell surface export of newly synthesized proteins, particularly Toll-like receptors and integrins. It is located in the endoplasmic reticulum and is essential for proper protein folding and preventing protein misfolding and aggregation. This protein is essential for both innate and adaptive immunity, and its dysfunction has been linked to various diseases, including cancer and glaucoma. HSP90B1 has been investigated as a target for cancer immunotherapy, with tumor-derived forms undergoing clinical trials as potential therapeutic agents. |
检测原理