Overview
| 别名 | Small nuclear ribonucleoprotein-associated proteins B and B'; snRNP-B; Sm protein B/B'; Sm-B/B'; SmB/B' |
| 基因名 | SNRPB |
| UniProt ID | P14678 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4G7-J7-Y8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 24 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Small nuclear ribonucleoprotein polypeptides B and B1 (SNRPB) is a core nuclear protein component of the U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs), which serve as the essential building blocks of the spliceosome. It plays a critical role in pre-mRNA splicing by facilitating the removal of introns and the joining of exons. Beyond its primary role in the major spliceosome, SNRPB contributes to minor U12-type intron splicing and histone pre-mRNA 3'-end processing through its association with the U7 snRNP. The protein interacts with the survival motor neuron (SMN) complex for snRNP biogenesis and is regulated by post-translational modifications such as arginine methylation. Clinically, mutations in SNRPB are the primary cause of cerebro-costo-mandibular syndrome, a rare skeletal dysplasia characterized by micrognathia and rib defects. Additionally, its overexpression is linked to oncogenesis in several cancers, including ovarian and hepatocellular carcinoma, where it drives proliferation and therapy resistance through dysregulated splicing. |
检测原理