Overview
| 别名 | Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; Interleukin-15 receptor subunit beta; p70-75; p75; CD antigen CD122 |
| 基因名 | IL2RB |
| UniProt ID | P14784 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5V2-K5-Y9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 61 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Interleukin 2 receptor subunit beta (IL2RB), also known as CD122, is a type I membrane protein that plays a crucial role in the immune system by forming part of the interleukin-2 (IL-2) receptor complex. The protein consists of 220 amino acids, has a molecular weight of approximately 25.5 kDa, and is glycosylated, which contributes to its functional properties. Its expression is primarily found in hematopoietic tissues, highlighting its importance in immune responses. It exists in three forms based on its binding affinity to IL-2: a low-affinity monomer (alpha subunit), an intermediate-affinity heterodimer (alpha/beta), and a high-affinity heterotrimer (alpha/beta/gamma), which are essential for T cell activation and proliferation. Dysregulation or mutations in IL2RB are associated with several diseases, including immunodeficiency disorders characterized by lymphoproliferation and autoimmunity, as well as ichthyosis. |
检测原理