Overview
| 别名 | Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2] |
| 基因名 | Aggrecan |
| UniProt ID | P16112 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4Q8-V8-B5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 261 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Aggrecan core protein (ACAN) is a large proteoglycan predominantly found in cartilage, playing a vital role in maintaining the structural integrity and resilience of the extracellular matrix. It consists of a core protein with multiple glycosaminoglycan (GAG) chains, primarily chondroitin sulfate and keratan sulfate, which contribute to its ability to retain water and provide compressive strength to cartilage. ACAN is essential for normal cartilage function, facilitating the mechanical properties necessary for joint movement and load-bearing. Beyond its structural role, ACAN also participates in signaling pathways that regulate cell behavior and tissue homeostasis. Dysregulation or mutations in the ACAN gene have been linked to various skeletal disorders, including osteoarthritis and multiple forms of skeletal dysplasia, where impaired cartilage function leads to joint pain and mobility issues. |
检测原理