Overview
| 别名 | Synapsin-1; Brain protein 4.1; Synapsin I |
| 基因名 | SYN1 |
| UniProt ID | P17600 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 7B8-K4-A9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 74 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Synapsin I (SYN1) is a neuronal phosphoprotein that plays a fundamental role in regulating synaptic vesicle trafficking and neurotransmitter release. It is localized to the cytoplasmic surface of synaptic vesicles, where it mediates their attachment to the actin cytoskeleton, thereby maintaining a reserve pool of vesicles. The protein exists as two major isoforms, Ia and Ib, which share a conserved N-terminal globular domain containing multiple phosphorylation sites for kinases such as cAMP-dependent protein kinase, Ca2+/calmodulin-dependent protein kinase (CaMKII), and MAP kinase. Upon neuronal depolarization, phosphorylation by these kinases triggers the dissociation of Synapsin I from vesicular membranes, facilitating vesicle mobilization to the active zone. Mutations in the SYN1 gene are linked to X-linked intellectual developmental disorder 50 and X-linked epilepsy, often presenting with seizures and behavioral challenges. |
检测原理