Overview
| 别名 | Vinculin; Metavinculin; MV |
| 基因名 | VCL |
| UniProt ID | P18206 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4B9-U1-P6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 123 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Vinculin (VCL), encoded by the VCL gene on chromosome 10, is a 117-kDa cytoskeletal protein with 1066 amino acids, featuring an acidic N-terminal globular head domain (binding talin, α-actinin, tyrosine phosphorylation site) and a basic C-terminal tail (binding F-actin, paxillin, lipids), linked by a proline-rich region, enabling its switch between autoinhibited (head-tail interaction) and active conformations triggered by talin binding for focal adhesion dynamics. It anchors F-actin to integrins at cell-matrix and cell-cell junctions, regulating cell spreading, motility, morphology, E-cadherin expression, and mechanosensing, with splice variant meta-vinculin (~150 kDa) in muscles. VCL defects cause dilated cardiomyopathy 1W (ventricular dilation, systolic dysfunction, heart failure, arrhythmia) and familial hypertrophic cardiomyopathy 15; loss impairs adhesion/stress fibers, while overexpression enhances recruitment. |
检测原理