Overview
| 别名 | Syndecan-1; SYND1; CD antigen CD138 |
| 基因名 | Syndecan-1 |
| UniProt ID | P18827 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgM |
| 克隆号 | 7M4-J3-G6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 32 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Syndecan 1 (Syndecan-1), also designated CD138, is a type I transmembrane heparan sulfate proteoglycan that serves as a versatile coreceptor on the cell surface. Its extracellular domain carries glycosaminoglycan chains that bind various extracellular matrix proteins, integrins, and growth factors such as FGF and VEGF, thereby enhancing signaling through pathways like PI3K-Akt and Ras-MAPK. The cytoplasmic domain anchors the protein to the cytoskeleton via ezrin and tubulin, maintaining epithelial morphology and cell adhesion. Proteolytic shedding of the ectodomain produces soluble Syndecan-1, which can act as a paracrine signaling molecule or a decoy receptor. Clinically, Syndecan-1 dysregulation is a major driver of tumor proliferation, invasion, and metastasis, particularly in multiple myeloma and Hodgkin's lymphoma. It also plays a significant role in modulating leukocyte-endothelial interactions during chronic inflammation. |
检测原理