Overview
| 别名 | Thymidine phosphorylase; TP; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase |
| 基因名 | TYMP |
| UniProt ID | P19971 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9O2-U7-U8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 49 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, is a crucial enzyme involved in pyrimidine metabolism, specifically catalyzing the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. The enzyme's properties include its dimeric structure and specific binding sites that facilitate its catalytic function. This protein, which functions as a homodimer, plays a vital role in maintaining nucleoside homeostasis necessary for DNA repair and replication, with its activity being essential for mitochondrial DNA integrity. Dysregulation or mutations in the TYMP gene are linked to several diseases, notably mitochondrial neurogastrointestinal encephalopathy (MNGIE) syndrome, characterized by mitochondrial dysfunction and severe neurological symptoms due to impaired thymidine salvage pathways. Additionally, TYMP is implicated in cancer biology; its expression is often elevated in various tumors, promoting angiogenesis and tumor growth. |
检测原理