Overview
| 别名 | Aromatic-L-amino-acid decarboxylase; AADC; DOPA decarboxylase; DDC |
| 基因名 | DOPA Decarboxylase |
| UniProt ID | P20711 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1S5-A9-U6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 53 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Dopa decarboxylase (DOPA Decarboxylase) is a pyridoxal 5'-phosphate-dependent enzyme essential for the synthesis of the biogenic amines dopamine and serotonin. It functions as a homodimer, catalyzing the decarboxylation of L-DOPA and L-5-hydroxytryptophan in the brain, peripheral nervous system, and kidneys. The enzyme's activity is tightly regulated by phosphorylation and receptor-mediated signaling to maintain neurotransmitter balance. Clinically, a genetic deficiency in Dopa decarboxylase leads to aromatic L-amino acid decarboxylase deficiency, a severe neurometabolic disorder characterized by developmental delay and movement disorders. Furthermore, dysregulation of this enzyme is a central feature of Parkinson's disease, where its role in converting therapeutic L-DOPA into dopamine is critical for symptom management. |
检测原理