Overview
| 别名 | Ras GTPase-activating protein 1; GAP; GTPase-activating protein; RasGAP; Ras p21 protein activator; p120GAP |
| 基因名 | RASA1 |
| UniProt ID | P20936 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2K9-B2-D9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 116 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | RAS p21 protein activator 1 (RASA1), also known as p120-RasGAP, is a cytoplasmic protein that functions as a key negative regulator of the RAS/MAPK signaling pathway, which is crucial for controlling cell proliferation, differentiation, and movement. Structurally, RASA1 contains several domains, including SH2, SH3, C2A, C2B, GAP, and PH, enabling it to interact with various signaling molecules and enhance the intrinsic GTPase activity of RAS proteins, thereby converting active RAS-GTP to its inactive GDP-bound form and suppressing RAS signaling. RASA1 is also involved in physiological processes such as angiogenesis, apoptosis, and the development of the vascular system, and its activity is regulated by intracellular calcium levels and membrane association. Pathogenic mutations or epigenetic inactivation of RASA1 are linked to vascular anomalies, such as capillary malformation-arteriovenous malformation (CM-AVM) syndrome, and have been implicated in the development of various cancers due to dysregulated RAS signaling. |
检测原理