Overview
| 别名 | Fibroblast growth factor receptor 2; FGFR-2; K-sam; KGFR; Keratinocyte growth factor receptor; CD antigen CD332 |
| 基因名 | FGFR2 |
| UniProt ID | P21802 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8J2-H4-P5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 92 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane protein that spans the cell membrane with one end inside the cell and the other projecting from the outer surface. It functions as a receptor for fibroblast growth factors, triggering chemical reactions that regulate critical cellular processes including proliferation, differentiation, bone development, angiogenesis, wound healing, and embryonic development. FGFR2 plays a crucial role in bone growth and remodeling, particularly during embryonic development where it signals immature cells to become bone cells and form tissues such as the head, hands, and feet. The protein exists in several isoforms with tissue-specific expression patterns that may change throughout development. Mutations in FGFR2 are associated with various skeletal disorders and conditions affecting bone formation. Recent research indicates that FGFR2 promotes proliferation, migration, and invasion of ectopic stromal cells through activation of extracellular signaling pathways. |
检测原理