Overview
| 别名 | Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide; GMAP] |
| 基因名 | GAL |
| UniProt ID | P22466 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1Q4-T8-T1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 13 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Galanin peptides (GAL) are a family of neuropeptides, widely expressed in the central and peripheral nervous systems, as well as in non-neuronal tissues. The galanin family includes several members, such as galanin itself, galanin-like peptide (GALP), and alarin, which all interact with three G protein-coupled receptors (GALR1, GALR2, and GALR3). Galanin plays a crucial role in various physiological functions, including modulation of neurotransmitter release, regulation of pain perception, appetite control, and cognitive processes. Dysregulation of galanin signaling has been implicated in several diseases. For instance, elevated levels of galanin have been associated with neurodegenerative conditions like Alzheimer's disease and epilepsy, where it may contribute to neuroprotection or exacerbate seizures. Additionally, alterations in galanin expression are linked to mood disorders such as depression and anxiety, as well as metabolic disorders like obesity. |
检测原理