Overview
| 别名 | Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6; Alpha6p] |
| 基因名 | Integrin alpha-6 |
| UniProt ID | P23229 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7R1-N2-D2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 126 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Integrin subunit alpha 6 (ITGA6) is a crucial membrane protein that forms part of the integrin family, which are heterodimeric receptors composed of alpha and beta chains. ITGA6 primarily associates with beta 4 (α6β4) and beta 1 (α6β1) to facilitate cell adhesion and signaling, particularly in epithelial cells where it plays a vital role in maintaining skin integrity through hemidesmosomes. Mutations in the ITGA6 gene are linked to several diseases, most notably epidermolysis bullosa with pyloric atresia (EB-PA), characterized by severe skin blistering and gastrointestinal obstructions due to compromised cell adhesion. Additionally, ITGA6 is implicated in the progression of various carcinomas, including prostate cancer, where altered expression and localization of α6β1 and α6β4 integrins enhance tumor cell migration and resistance to apoptosis. |
检测原理