Overview
| 别名 | Eukaryotic translation initiation factor 4B; eIF-4B |
| 基因名 | EIF4B |
| UniProt ID | P23588 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5C2-A3-K2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 69 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Eukaryotic translation initiation factor 4B (eIF4B) is a protein that plays a central role in promoting translation initiation by helping to unwind secondary structures within mRNA's 5' untranslated regions (UTRs). It functions by stimulating the helicase activity of eIF4A and interacting with eIF3 and the 18S ribosomal RNA. eIF4B is essential for translating mRNAs with complex secondary structures, many of which encode proteins involved in vital cellular processes. Its activity is regulated through phosphorylation events, particularly by the mTOR/PI3K and MAPK pathways, and it is subject to post-transcriptional modification. Overexpression of eIF4B has been linked to cancer progression due to its influence on the translation of pro-survival mRNAs. |
检测原理