Overview
| 别名 | Paired box protein Pax-3; HuP2 |
| 基因名 | PAX3 |
| UniProt ID | P23760 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 4U4-I8-C6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 52 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Paired box 3 (PAX3) is a transcription factor characterized by highly conserved N-terminal DNA-binding domains, including a paired box and a homeodomain, alongside a C-terminal transactivation domain. It plays a critical role in neural crest cell development, myogenesis, and the regulation of cell proliferation and apoptosis. PAX3 often synergizes with SOX10 to activate the transcription of MITF, a key regulator of melanocyte development. The protein undergoes various post-translational modifications, such as phosphorylation and ubiquitination, which modulate its activity and stability. Mutations in the PAX3 gene are well-established causes of Waardenburg syndrome types I and III, as well as craniofacial-deafness-hand syndrome. Furthermore, the PAX3-FOXO1A chromosomal translocation is a hallmark of alveolar rhabdomyosarcoma, where the resulting fusion protein drives uncontrolled muscle cell growth and evades apoptosis. |
检测原理