Overview
| 别名 | DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; 3'-5' exoribonuclease; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1 |
| 基因名 | RNA Polymerase II Subunit B1 |
| UniProt ID | P24928 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2P3-F1-Y1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 217 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | RNA polymerase II subunit A (POLR2A) is the largest subunit of RNA polymerase II, a crucial enzyme responsible for synthesizing messenger RNA (mRNA) in eukaryotic cells. This protein plays a pivotal role in transcription regulation, facilitating the conversion of DNA into RNA, which is essential for gene expression. POLR2A is widely expressed across various tissues, including the brain, liver, and lungs, indicating its fundamental importance in cellular function and development. Mutations or dysregulation of POLR2A have been linked to several diseases, particularly cancers such as breast and lung cancer, where altered expression levels can affect tumor progression and response to therapy. Additionally, POLR2A has been implicated in neurodegenerative diseases due to its role in neuronal gene expression. |
检测原理