Overview
| 别名 | Proteasome subunit alpha type-1; 30 kDa prosomal protein; PROS-30; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; Proteasome nu chain; Proteasome subunit alpha-6; alpha-6 |
| 基因名 | PSMA1 |
| UniProt ID | P25786 |
| 反应种属 | Human,Mouse |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9Z3-I7-E8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 29 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Proteasome 20S subunit alpha 1 (PSMA1) is a protein encoded by the PSMA1 gene in humans. It is one of the 17 essential subunits that contribute to the complete assembly of the 20S proteasome complex, which is crucial for the degradation of intracellular proteins. The 20S proteasome is composed of four stacked rings, two alpha and two beta rings, with the beta rings forming a proteolytic chamber and the alpha rings forming the entrance for substrates. PSMA1, also known as proteasome subunit alpha type-1, encodes the α6 subunit that makes up the outer ring of the 20S core particle. This protein plays a significant role in various biological processes, including protein quality control and the processing of class I MHC peptides. In disease contexts, PSMA1 has been implicated in tumor progression and poor prognosis in gastric carcinoma by deubiquitinating and stabilizing TAZ. |
检测原理