Overview
| 别名 | Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8; Proteasome subunit alpha-7; alpha-7 |
| 基因名 | PSMA3 |
| UniProt ID | P25788 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4W3-I2-E3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 28 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Proteasome 20S subunit alpha 3 (PSMA3) is a crucial component of the 20S core proteasome complex, responsible for the proteolytic degradation of most intracellular proteins. This 28.4 kDa protein, composed of 254 amino acids, contributes to the formation of heptameric alpha rings and the substrate entrance gate. PSMA3 plays a vital role in protein quality control, regulatory protein degradation, and antigen processing for MHC class I presentation. It interacts with various regulatory particles to form the 26S proteasome, which degrades ubiquitinated proteins in an ATP-dependent manner. In terms of disease associations, PSMA3 has been implicated in cancer progression, particularly in esophageal squamous cell carcinoma (ESCC). Abnormal expression of PSMA3 is linked to cancer stemness and immunomodulation, with studies showing its involvement in suppressing CD8+ T-cell infiltration through regulation of chemokine CCL3. |
检测原理