Overview
| 别名 | ELAV-like protein 4; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD |
| 基因名 | ELAVL4 |
| UniProt ID | P26378 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 9I1-A9-M7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 42 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | ELAVL4 (ELAV Like RNA Binding Protein 4) is a post-transcriptional regulator that functions as an RNA-binding protein containing three RNA recognition motif domains that preferentially bind AU-rich elements in the 3'-UTR of target mRNAs. The protein stabilizes mRNAs by preventing exonuclease-mediated degradation and regulates mRNA translation, alternative splicing, and stability of neuronal transcripts including GAP43, ACHE, and BDNF. ELAVL4 plays critical roles in neuronal differentiation, dendritic arbor maturation, and synaptic function by promoting neural stem cell differentiation in the hippocampus. Dysregulation of ELAVL4 is implicated in Alzheimer's disease, where reduced expression increases APP isoforms and phosphorylated tau levels, while ELAVL4 overexpression reduces amyloid-beta pathology and ameliorates AD-related molecular changes. Additionally, ELAVL4 dysfunction contributes to small cell lung cancer tumorigenesis and pancreatic neuroendocrine tumors through altered regulation of oncogenic transcripts. |
检测原理