Overview
| 别名 | Serum paraoxonase/arylesterase 1; PON 1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1 |
| 基因名 | PON1/PON2 |
| UniProt ID | P27169 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7A9-I1-Z2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 39 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Serum paraoxonase/arylesterase 1 (PON1) is a calcium-dependent enzyme that is primarily associated with high-density lipoproteins (HDL) and plays a significant role in lipid metabolism and antioxidant defense. It is involved in the hydrolysis of various substrates, including organophosphates and oxidized lipids, contributing to its atheroprotective properties by preventing the accumulation of oxidized low-density lipoprotein (LDL) cholesterol. Variations in the PON1 gene, particularly polymorphisms such as Q192R and L55M, can significantly affect enzyme activity and serum levels, influencing individual susceptibility to cardiovascular diseases. Low PON1 activity has been linked to an increased risk of atherosclerosis, diabetes, and neurodegenerative diseases. |
检测原理