Overview
| 别名 | Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta |
| 基因名 | HIF1-beta |
| UniProt ID | P27540 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9C2-F8-J4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 86 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that plays a crucial role in cellular responses to environmental stimuli, particularly in the context of hypoxia and exposure to xenobiotic compounds. ARNT is characterized by its basic helix-loop-helix (bHLH) and PAS domains, which enable it to form heterodimers with other proteins, such as the aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor (HIF) subunits. This protein is involved in regulating gene expression related to oxygen homeostasis and the metabolism of environmental toxins. Dysregulation of ARNT has been associated with various diseases, including certain cancers; for instance, translocations involving the *ARNT* gene can lead to acute myeloblastic leukemia. Additionally, aberrant ARNT signaling may contribute to tumor progression by altering the expression of genes involved in cell survival and proliferation. |
检测原理