Overview
| 别名 | Hematopoietic progenitor cell antigen CD34; CD antigen CD34 |
| 基因名 | CD34 |
| UniProt ID | P28906 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4R7-L6-P6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 40 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CD34 molecule (CD34) is a type I transmembrane sialomucin glycoprotein characterized by a heavily glycosylated extracellular region and a short cytoplasmic signaling tail. It is widely recognized as a primary marker for hematopoietic stem and progenitor cells (HSPCs) and endothelial progenitor cells, with expression typically lost during terminal differentiation. Functionally, CD34 serves as a context-dependent adhesion molecule; it facilitates the attachment of stem cells to the bone marrow stroma and extracellular matrix through interactions with L-selectin and CrkL. It also plays a role in lymphocyte trafficking by enabling adhesion to high endothelial venules. In addition to its adhesive properties, CD34 can exhibit anti-adhesive effects that support cell migration. Intracellularly, it modulates signaling pathways that regulate progenitor cell proliferation and inhibit premature differentiation. |
检测原理