Overview
| 别名 | T-cell surface glycoprotein CD1c; CD antigen CD1c |
| 基因名 | CD1C |
| UniProt ID | P29017 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3M6-X5-V9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 37 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CD1c molecule (CD1C) is a transmembrane glycoprotein belonging to the CD1 family, structurally related to Major Histocompatibility Complex (MHC) proteins. It forms heterodimers with beta-2-microglobulin and specializes in presenting lipid and glycolipid antigens, both self and microbial, to T-cell receptors on natural killer T-cells. Unlike other CD1 isoforms, CD1c features a unique open F′ groove that allows it to accommodate diverse lipid antigens, including those with methyl-branched structures. This structural adaptation enables CD1c to bind and present antigens such as mannosyl-β1-phosphomycoketide (MPM) from Mycobacterium tuberculosis, playing a critical role in immune responses. The protein is broadly distributed throughout the endocytic system, guided by a tyrosine-based motif in its cytoplasmic tail. Diseases associated with CD1c include histiocytosis and follicular dendritic cell sarcoma. |
检测原理