Overview
| 别名 | Inositol monophosphatase 1; IMP 1; IMPase 1; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1 |
| 基因名 | IMPA1 |
| UniProt ID | P29218 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6R3-H6-F4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 30 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Inositol monophosphatase 1 (IMPA1) is an enzyme responsible for dephosphorylating myo-inositol monophosphate to generate free myo-inositol, which serves as a precursor for phosphatidylinositol synthesis. Located in the cytoplasm, IMPA1 plays a crucial role in maintaining normal brain function by providing inositol required for the synthesis of phosphatidylinositols and polyphosphoinositides. The enzyme is encoded by the IMPA1 gene in humans and is part of the essential phosphatidylinositol signaling pathway. In terms of disease associations, IMPA1 in promoting triple-negative breast cancer progression through its regulation of the mTOR pathway and epithelial-mesenchymal transition (EMT) process. Additionally, IMPA1 is a target of lithium, which inhibits the enzyme to induce autophagy, suggesting its potential involvement in mood disorders and other neuropsychiatric conditions for which lithium is prescribed. |
检测原理