Overview
| 别名 | Peroxiredoxin-6; 1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2; aiPLA2; Antioxidant protein 2; Glutathione-dependent peroxiredoxin; Liver 2D page spot 40; Lysophosphatidylcholine acyltransferase 5; LPC acyltransferase 5; LPCAT-5; Lyso-PC acyltransferase 5; Non-selenium glutathione peroxidase; NSGPx; Red blood cells page spot 12 |
| 基因名 | Peroxiredoxin-6 |
| UniProt ID | P30041 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6T4-O9-Y4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 25 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Peroxiredoxin 6 (PRDX6) is a multifunctional enzyme that plays a crucial role in protecting cells from oxidative stress. It is a member of the peroxiredoxin family of antioxidant enzymes and is widely distributed in various organs, particularly in the lungs. PRDX6 has two distinct active sites, enabling it to reduce hydrogen peroxide (H2O2) and short-chain organic, fatty acid, and phospholipid hydroperoxides, thereby protecting cells from oxidative injury. It also exhibits phospholipase A2 (PLA2) activity, which is essential for the repair of peroxidized cell membranes and the regulation of phospholipid turnover. PRDX6 has been implicated in various diseases, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, where its PLA2 activity can either protect against or exacerbate oxidative stress depending on the context. Overall, PRDX6 is a critical enzyme for maintaining cellular redox balance and preventing oxidative damage. |
检测原理