Overview
| 别名 | Flavin reductase; NADPH; FR; Biliverdin reductase B; BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR; S-nitroso-CoA-assisted nitrosyltransferase; SNO-CoA-assisted nitrosyltransferase |
| 基因名 | BLVRB |
| UniProt ID | P30043 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 5P6-H1-R8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 22 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Biliverdin reductase B (BLVRB) is a monomeric enzyme that functions as a critical cellular redox regulator by catalyzing the NADPH-dependent reduction of various substrates, including biliverdin and flavins. It features a dinucleotide-binding fold that undergoes conformational changes upon coenzyme binding to facilitate its catalytic activity. Beyond its role in maintaining redox homeostasis, BLVRB exhibits dual-specificity kinase activity and participates in cell signaling pathways that defend against oxidative stress and endothelial dysfunction. The enzyme's promiscuous catalytic nature allows it to dictate cellular fate under different physiological conditions. Clinically, BLVRB is recognized as a potential target for managing neonatal jaundice and as an adjunct therapy in organ transplantation to maintain protective biliverdin levels. |
检测原理