Overview
| 别名 | Aldehyde dehydrogenase; dimeric NADP-preferring; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1 |
| 基因名 | ALDH3A1 |
| UniProt ID | P30838 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9K4-P1-R8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 50 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Aldehyde dehydrogenase 3 family member A1 (ALDH3A1) is a cytoplasmic homodimeric enzyme that plays a vital role in cellular detoxification and metabolic processes. It primarily functions by oxidizing medium- and long-chain aldehydes, including acetaldehyde derived from alcohol metabolism, into nontoxic fatty acids. ALDH3A1 is also involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and products of lipid peroxidation. Notably, this protein constitutes approximately 50% of the soluble protein content in the corneal epithelium, where it protects ocular structures from oxidative damage induced by UV radiation and 4-hydroxy-2-nonenal. By maintaining redox homeostasis, ALDH3A1 preserves the integrity of tissues exposed to environmental stress. Clinically, mutations or dysregulation of ALDH3A1 are associated with ocular and metabolic disorders, including Keratoconus and Sjogren-Larsson Syndrome. |
检测原理